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. 2018 Jan 1;24(1-2):57–67. doi: 10.1089/ten.tea.2016.0527

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© Michael G. Monaghan et al. 2018; Published by Mary Ann Liebert, Inc.

This article is available under the Creative Commons License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use and can be done via RightsLink.

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FIG. 2. — (A) Morphometric data at 2 dpi and 2 and 5 wpi with treatment of miR-239B (control) or miR-29B. Asterisk (*) indicates a statistically significant improvement in EF. # Indicates a statistically significant deterioration in the cardiac function of animals treated with miR-239B when compared to the initial measurement at 2 days post infarction (p < 0.05). (B) Quantification of scar area as a percentage of the total tissue cross section. No significant difference was detected between miR-239B and miR-29B at 5 weeks post ischemia. Picrosirius red/fast green-stained sections of hearts treated with (C) miR-239B and (D) miR-29B. Scale bar: 2 mm. Red staining in the ventricular tissue represents fibrotic ischemic scar tissue at 5 weeks. dpi, days postinfarction; EF, ejection fraction; wpi, weeks postinfarction.