Table 2.

Published clinical sequencing studies in pediatric oncology

Study	Institution	Tumor types	Patient population	No. of patients analyzed	% Actionable alterations	Year published	PMID
Peds-MiOncoSeq	University of Michigan	Solid (including CNS) and hematologic malignancies	Relapsed/refractory, high-risk newly diagnosed	91	46	2015	26325560
iCat	Dana-Farber Cancer Institute and others	Extracranial solid tumors	Relapsed/refractory, high-risk newly diagnosed	89	34	2016	26822149
BASIC3	Baylor College of Medicine	Solid (including CNS)	Newly diagnosed	150	39	2016	26822237
INFORM	German Cancer Research Center and others	Solid (including CNS) and hematologic malignancies	Relapsed/refractory	52	50	2016	27479119
MBB Program	Institut Curie, France	Solid (including CNS)	Relapsed/refractory, high-risk newly diagnosed	58	40	2016	27896933
PIPseq	Columbia University Medical Center	Solid (including CNS) and hematologic malignancies	Relapsed/refractory, high-risk newly diagnosed	101	38	2016	28007021
MOSCATO-01	Gustave Roussy, France	Solid (including CNS)	Relapsed/refractory	69	61	2017	28733441

CNS, central nervous system, INFORM, individualized therapy for relapsed malignancies.