Table 2.
Summary of Pharmacokinetic Parameters of 13C6-LT4 After Oral Administration
| Median (range) | |||
|---|---|---|---|
| Parameter | All ages | Age ≤60 years (n = 31) | Age >60 years (n = 10) |
| CL/F (L/h) | 0.712 (0.244–2.91) | 0.712 (0.244–2.91) | 0.796 (0.301–1.74) |
| V/F (L) | 164.9 (34.02–587.52) | 174.7 (34–504.2) | 157.4 (100.7–587.5) |
| Tmax (h) | 4 (1.5–24) | 4 (1.5–24) | 5 (2.5–8) |
| Dose-normalized Cmax (ng/L μg) | 7.5 (2–20) | 7.5 (2–20) | 7.1 (2.3–13) |
| Dose-normalized AUC0–120 (ng/h.mL/μg) | 0.931 (0.288–2.84) | 0.931(0.288–2.84) | 1.01 (0.339–1.99) |
| Dose-normalized AUC0–∞ (ng/h.mL/μg) | 1.41 (0.344–4.09) | 1.41(0.344–4.09) | 1.36 (0.576–3.33) |
| t1/2 (h) of the terminal distribution phase | 172.2 (51.36–310.8) | 166 (54.1–265.7) | 206.4 (109.4–310.8) |
CL/F, oral clearance rate; V/F, volume of distribution; Tmax, time to peak concentration; Cmax, peak concentration; AUC1–120, area under the concentration–time curve from time 0 to 120 hours; AUC0–∞, area under the concentration–time curve from time 0 to infinity; t1/2, the half-life of the terminal disposition phase.