Table 5.
Summary of Molecular Testing Results Comparing Adult (n = 257) to Pediatric (n = 115) Specimensa
| Proportion [CI] | |||
|---|---|---|---|
| Metric | Histopathology | Adult >19 years | Pediatric <18 years |
| Specificity | All benign | 86% [79–92%] | 98% [89–100%] |
| Follicular adenoma | 77% [65–87%] | 97% [82–100%] | |
| Other benign | 98% [89–100%] | 100% [89–100%] | |
| Sensitivity | All carcinomas | 56% [47–64%] | 47% [35–60%] |
| Follicular carcinoma | 26% [13–43%] | 33% [4–78%] | |
| PTC, classical variant | 79% [60–92%] | 63% [42–81%] | |
| PTC, follicular variant | 44% [28–62%] | 33% [16–55%] | |
| Other carcinomas | 75% [60–87%] | 45% [17–77%] | |
a
Based on the relative distribution of various histopathological categories reported in Giordano et al. for adults (31) and in the present study for pediatrics.