. 2018 Jan 1;28(1):23–31. doi: 10.1089/thy.2017.0227

Table 2.

Results and Findings of Observation for Low-Risk PMC at Kuma Hospital and the Cancer Institute Hospital

Kuma Hospital	Cancer Institute Hospital
1. Of 1235 patients, 8% and 3.8% showed size enlargement and novel node metastasis, respectively, at 10-year observation (15). 2. The PMCs of young patients are likely to progress, and those of old patients are most unlikely to grow (15). 3. None of the patients who underwent surgery after the detection of progression signs showed significant recurrence or died of PTC (15). 4. Only 8% of the patients showed PMC progression during pregnancy, and rescue surgery after delivery was successful (29). 5. Immediate surgery and active surveillance managements had similarly excellent oncological outcomes. However, the immediate surgery resulted in significantly higher incidences of unfavorable events than the active surveillance management did (20). 6. The Ki-67 LI was higher in PMCs resected due to tumor enlargement than in PMCs without tumor enlargement (26). 7. The total cost of immediate surgery, including the costs for salvage surgery and postoperative care for 10 years, was 4.1 times the total cost of 10-year management for active surveillance (31).	1. Of 230 patients (300 lesions), 7% and 1% showed size enlargement and novel node metastasis, respectively, during observation (19). 2. None of the patients who underwent surgery after the detection of progression signs showed significant recurrence or died of PTC (19). 3. The TSH value was not linked to the progression of PMC during observation (25). 4. PMCs with a rich blood supply or a lack of strong calcification on ultrasound displayed high growth activity; rich vascularity often decreased over time (23).

Kuma Hospital

Cancer Institute Hospital

1. Of 1235 patients, 8% and 3.8% showed size enlargement and novel node metastasis, respectively, at 10-year observation (15).
2. The PMCs of young patients are likely to progress, and those of old patients are most unlikely to grow (15).
3. None of the patients who underwent surgery after the detection of progression signs showed significant recurrence or died of PTC (15).
4. Only 8% of the patients showed PMC progression during pregnancy, and rescue surgery after delivery was successful (29).
5. Immediate surgery and active surveillance managements had similarly excellent oncological outcomes. However, the immediate surgery resulted in significantly higher incidences of unfavorable events than the active surveillance management did (20).
6. The Ki-67 LI was higher in PMCs resected due to tumor enlargement than in PMCs without tumor enlargement (26).
7. The total cost of immediate surgery, including the costs for salvage surgery and postoperative care for 10 years, was 4.1 times the total cost of 10-year management for active surveillance (31).

1. Of 230 patients (300 lesions), 7% and 1% showed size enlargement and novel node metastasis, respectively, during observation (19).
2. None of the patients who underwent surgery after the detection of progression signs showed significant recurrence or died of PTC (19).
3. The TSH value was not linked to the progression of PMC during observation (25).
4. PMCs with a rich blood supply or a lack of strong calcification on ultrasound displayed high growth activity; rich vascularity often decreased over time (23).

TSH, thyrotropin.