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. Author manuscript; available in PMC: 2018 Jan 16.
Published in final edited form as: J Alzheimers Dis. 2017;60(3):1143–1160. doi: 10.3233/JAD-170634

Fig 9.

Fig 9

Accumulation of lysosomal marker (LAMP1) and co-localization with Aβ marker, 6E10, p-tau and GMF. Double immunofluorescence staining on postmortem brain temporal cortex of AD and non-AD brain. (A) Sections immunostained with anti-LAMP1 and 6E10, respectively displayed higher accumulation and co-localization of LAMP1 and 6E10 in AD compared with non-AD. (C) Sections immunostained with anti-LAMP1 and anti-p-tau respectively, displayed higher accumulation and co-localization of LAMP1 with p-tau in AD compared with non-AD. (E) Sections immunostained with anti-LAMP1 and anti-GMF respectively, displayed higher accumulation and co-localization of LAMP1 with GMF in AD compared with non-AD Data were analyzed as mean ± standard error, from each group (n= 3–5). *p <0.05 versus non-AD was considered statistically significant. Zoom of boxed area showed the enlarge view of co-localization of LAMP1 (red) with 6E10 (green), p-tau (green) and GMF (green) Scale bar = 50 μm and AU (Arbitrary Unit). (B, D, F) Quantification of LAMP1, 6E10, p-tau and GMF based on average labeled intensity and labeled positive area in AD and non-AD brains.