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. Author manuscript; available in PMC: 2018 Jan 16.
Published in final edited form as: Immunity. 2016 Nov 15;45(5):1108–1121. doi: 10.1016/j.immuni.2016.10.027

Figure 4. N6 Tolerates Mutations in the CD4 BLP and V5.

Figure 4

(A) Neutralization of N6 against three N6-resistant and the Z258 autologous pseudoviruses. Neutralization of these pseudoviruses with reverse mutations in loop D, CD4 BLP, and V5 region are also shown. Sequence variations of gp120, as compared to reference sequences, are listed in bold red. Reverse mutations are highlighted in bold and underlined.

(B) Details of the structural interaction between N6 and HIV-1 gp120 loop D.

(C) Details of the structural interaction between N6 and HIV-1 gp120 CD4-binding loop C.

(D) Details of the structural interaction between N6 and HIV-1 gp120 V5.

N6 components are shown in ribbon with key residues highlighted in sticks. HIV-1 loop D, CD4-binding loop, and V5 are shown in sticks. Color scheme is the same as Figure 2A. See also Figure S4 and Table S5.