Appendix 1—table 4. Average percentage of matches to various BPPS subgroup (BSG) patterns for haloacid dehalogenase sequences assigned to SFLD subgroup SG1135.

BSG		SG1135	% matches to each BSG pattern for SG1135 sequences*:										Mean score† vs others		new‡
ID	# seqs	# seqs	15	16	25	3	11	14	17	18	24	23	In SG1135	In BSG	SGs
15	1417	63	69	35	32	51	8	42	19	56	22	20	63	64	?
16	1008	1	43	40	52	52	12	40	40	52	24	8	110	14	error
25	387	311	48	37	84	57	13	36	43	45	27	10	80	309	yes
3	5447	4500	49	25	35	90	15	37	20	38	20	9	148	132	?
11	287	3	33	29	37	51	93	32	17	32	16	8	44	632	yes
14	1066	32	49	27	25	37	9	77	18	47	19	13	42	130	yes
17	518	288	41	39	41	42	8	30	88	48	25	6	55	321	yes
18	1455	950	58	34	28	44	9	50	16	88	20	15	43	169	yes
24	217	107	42	35	26	44	9	32	20	42	92	4	53	293	yes
23	227	125	62	32	23	41	4	32	10	36	14	90	45	403	yes
root	n.a.	3040	46	37	41	56	12	40	29	46	23	10	n.a.	n.a.	n.a.

*Average percentage of matches to the pattern residues for their assigned BSG among the SG1135 sequences. The highest percentages (bold) correspond to the highest percentage in each row.

^†The mean pairwise BLAST scores of the BPPS-assigned sequences against the remaining sequences either in SG1135 or in the BSG for that row. The highest scores in each row are bold. (See Appendix 1—table 2.).

^‡A ‘yes’ in this column indicates that the SG1135 sequences assigned to the BSG in that row likely correspond to a subgroup distinct from SG1135; ‘?’ indicates a possible subcategory of SG1135; ‘error’ indicates a BPPS misclassification.