Table 2. Structural diversity among proteins identified and aligned by MAPGAPS.

Superfamily	structures*		RMSD† (Å)				Domain length‡			Resolution (Å)
	% ID	No.	Avg	Min	Max	S.D.	MSA	Avg	S.D.	Avg	Max
GNAT	27	16	3.25	1.0	6.7	1.4	125	139.8	17.0	1.94	2.61
GTPases	30	20	3.96	0.6	14.7	3.5	164	195.9	41.6	2.31	3.10
Helicases	40	12	6.39	2.6	9.8	1.8	466	482.8	60.7	2.86	3.56
EEP	40	16	3.02	0.8	5.2	0.95	241	259.0	27.6	2.07	2.99
UDG/TDG	40	8	2.54	1.1	3.6	0.69	125	135.9	12.7	1.83	2.58

^*NMR and poor resolution structures were not used; no two proteins in each set contained more than the indicated level of percent sequence identity (% ID); pdb identifies for these are given in supplementary file 1.

^†RMSDs were computed using MUSTANG (Konagurthu et al., 2006) with default parameters; the structural coordinates used for the analysis were limited to the domain of interest.

^‡The number of aligned columns in the MSA, and the average length and standard deviation of the domain ‘footprint’.