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. 2018 Jan 10;4(1):e1701676. doi: 10.1126/sciadv.1701676

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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Fig. 8 — (A) AP curves for SR (blue) and cAF (red) as predicted by the original and median CRN model. Experimental calibration via POMs produces a model that fits very well the general trend of the data (mean values of biomarkers from the data indicated by dashed lines). (B) cAF APs before (red) and after (gold) treatment via I_Kr blocker for the original (dashed) and modified (solid) CRN model. Our median CRN model predicts the antiarrhythmic effects of I_Kr block (via APD prolongation), whereas the original CRN model predicts little response.