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Role of oxidative stress in the vascular damage
The production of ROS is increased in patients with diabetes, hypertension, dyslipidemia, obesity, smoking habit, etc. ROS react with components of the body such as fats, proteins, and nucleic acids to degenerate them. ROS induce erroneous expression of many genes through expression of redox-regulated genes, which leads to the onset and progression of atherosclerosis.
Abbreviation: ROS, reactive oxygen species.
