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. Author manuscript; available in PMC: 2018 Jan 16.
Published in final edited form as: Science. 2017 Jun 15;357(6348):273–279. doi: 10.1126/science.aan1052

Fig. 4. Extended-state activation of the nucleotide pockets is coupled to translocation.

Fig. 4

(A) Map and model of the P6, P1 and P2 nucleotide pockets. Arg-fingers, NBD1-R334 and NBD2-R765, are shown (green) with γ-phosphate contact indicated (*) for the active sites and distances shown for the inactive sites. Sensor 2 residues NBD1-R333 and the NBD2-R826 are shown (cyan). (B) Rotary translocation model showing closed-to-extended states resulting in active (green), inactive (red) and unbound/inactive (grey dash) states of the NBDs. Pore loop spiral (grey gradient) is shown contacting substrate (yellow). Arg-finger contact and NBD activation is depicted by the interlocking contact.