Table 3. Assessment of proposed nCLE criteria.

	Experts					Novices
	Sensitivity (%)	Specificity (%)	Accuracy (%)	Positive predictive value (%)	Negative predictive value (%)	Sensitivity (%)	Specificity (%)	Accuracy (%)	Positive predictive value (%)	Negative predictive value (%)
Dark aggregates > 40 µm or dilated irregular vessels with fluorescein leakage (95 %CI) (for malignancy)	80 (62 – 91)	5 (0 – 22)	58 (38 – 71)	67 (45 – 84)	9 (0 – 50)	78 (67 – 88)	24 (7 – 44)	63 (44 – 74)	71 (48 – 87)	31 (8 – 65)
Dark lobular structures/normal acinar cells (95 %CI) (for benign diagnosis)	50 (20 – 75)	82 (74 – 89)	74 (58 – 82)	47 (21 – 77)	83 (62 – 94)	50 (20 – 75)	89 (80 – 95)	82 (67 – 90)	65 (30 – 88)	87 (67 – 97)
Dark lobular structures/normal acinar cells or fine white fibrous bands (95 %CI) (for benign diagnosis	83 (67 – 93)	41 (26 – 59)	51 (36 – 64)	32 (13 – 55)	88 (60 – 97)	89 (67 – 100)	56 (33 – 73)	64 (43 – 76)	40 (16 – 68)	94 (72 – 100)

CI, confidence interval