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. 2018 Jan 12;8:973. doi: 10.3389/fphar.2017.00973

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Copyright © 2018 Lu, Chen, Gu, Ding, Zhao, Zhao, Yao, Chen, He and Cong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of ALCAM can promote HCC cell migration and invasion. Restoration of ALCAM reverses miR-483-5p-mediated HCC cell migration and invasion. (A) Transwell migration assay of SK-Hep1 and SMMC-7721 showed transfection of ALCAM siRNAs promoted cell migration. (B) Transwell invasion assay showed transfection of ALCAM siRNAs promoted cell invasion. (C) The migration of HCC cells induced by miR-483-5p was restored via ALCAM re-introduction. (D) The invasion of HCC cells induced by miR-483-5p was restored via ALCAM re-introduction. ^*p < 0.05; ^**p < 0.01 ×40.