Table 2.

Repeated measures ANOVA results for behavior testing.

Behavior	Interaction	Main effect	F(df,error) value	P-value
Open field
Horizontal distance moved	Genotype × treatment × epoch		F(4,366)= 0.255	0.919
	Treatment × epoch		F(4,366)= 2.292	0.054∼
	Genotype × epoch		F(4,366)= 0.559	0.707
	Genotype × treatment		F(1,84)= 0.270	0.605
		Genotype	F(1,84)= 8.154	0.005*
		Treatment	F(1,84)= 1.536	0.219
		Epoch	F(4,366)= 170.930	<0.001*
Center/total distance	Genotype × treatment × epoch		F(4,360)= 0.899	0.470
	Treatment × epoch		F(4,360)= 0.643	0.643
	Genotype × epoch		F(4,360)= 0.823	0.518
	Genotype × treatment		F(1,85)= 0.136	0.713
		Genotype	F(1,85)= 3.081	0.083∼
		Treatment	F(1,85)= 3.115	0.081∼
		Epoch	F(4,360)= 7.724	<0.001
Zero maze	Genotype × treatment		F(1,87)= 0.250	0.619
		Genotype	F(1,87)= 13.059	0.001*
		Treatment	F(1,87)= 5.111	0.026*
Passive avoidance	Genotype × treatment		F(1,74)= 0.045	0.832
		Genotype	F(1,74)= 5.004	0.028*
		Treatment	F(1,74)= 0.027	0.871
Sleep
Total sleep time	Genotype × treatment × phase		F(1,102)= 0.020	0.887
	Treatment × phase		F(1,102)= 0.236	0.628
	Genotype × phase		F(1,102)= 3.558	0.062∼
	Genotype × treatment		F(1,102)= 0.374	0.542
		Genotype	F(1,102)= 5.324	0.023*
		Treatment	F(1,102)= 4.056	0.047*
		Phase	F(1,102)= 1494.025	<0.001*

∼0.05 < p ≤ 0.1; ^∗p ≤ 0.05.