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. 2018 Jan 16;8:856. doi: 10.1038/s41598-018-19302-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Example of change of language activation over time in relation to language performance and vascular reactivity in stroke patients. Significant change of language activation (induced by a picture-word matching task) over time was found in left angular gyrus (red overlay (a)) (b) and left posterior inferior temporal gyrus (blue overlay (e)) (f), but not in right inferior frontal gyrus pars triangularis (green overlay (i)) (j). Language performance was significantly correlated with language activation in left posterior inferior temporal gyrus (g), but not in left angular gyrus (c) or right inferior frontal gyrus pars triangularis (k). Language activation was significantly correlated with vascular responsiveness (measured with a breath hold paradigm) in right inferior frontal gyrus pars triangularis (i), but not in left angular gyrus (d) or left posterior inferior temporal gyrus (h). See also Table 3. Statistical significance is indicated by [*].