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. 2018 Jan 16;8:823. doi: 10.1038/s41598-018-19341-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential mRNA expression in OSCC margins (A) Venn diagram illustrating the relationship between differentially expressed mRNAs in the three discrete comparisons: T vs WL (Blue Circle), T vs NBI (Red Circle), WL vs NBI (Green Circle). (B) Boxplots showing the expression profiles across the tumour margins of the 3 most upregulated and downregulated mRNA derived from the T vs NBI comparison. (C) Pathway analysis of dysregulated genes (mRNA) between the OSCC margins. Up and down regulated pathways were determined using GSEA and the MsigDb curated KEGG database genesets. Pathways are ranked according to normalised enrichment score generated by GSEA. Threshold of significance is shown by the dashed line.