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. 2018 Jan 16;8:823. doi: 10.1038/s41598-018-19341-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Circos plots of gene and miRNA differential expression and potential regulatory linkages for (A) tumour vs NBI and (B) tumour vs WL. Outermost track is chromosome mapping. Histogram plot tracks show differential gene (mRNA) expression as up (red) and down (blue) regulated (−Log(10) P-value). Dot plot tracks show differential microRNA (miRNA) expression as up (red) and down (blue) regulated (−Log(10) P-value). Innermost track (centre) shows correlated miRNA-mRNA linkages as reciprocal (purple) and non-reciprocal (orange). (C) Functional enrichment of the correlated miRNA-mRNA dataset by overrepresentation analysis of pathways and gene ontology. The target correlated mRNA were used with the EnrichR analysis tool to derive significantly perturbed pathways and gene ontology associations. The top 10 pathways/ontology terms for each analysis are shown ranked by the EnrichR combined score parameter. (D) Functional relationships of candidate miRNA-mRNA interactions mapped onto the Oncostatin M signalling network using Cytoscape. mRNA nodes are oval and miRNA nodes are rectangular. For both mRNA and miRNA upregulated nodes are red and downregulated are blue.