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. 2018 Jan 16;8:859. doi: 10.1038/s41598-018-19204-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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µCT analysis of the trabecular and cortical bone in Th10 and L2 vertebrae. (A) Regions of Interest (ROIs) of the trabecular (tbr) and cortical (cb) vertebrae are marked. (B–D). Trabecular number (Tb.N) (B), thickness (Tb.Th) (C) and open porosity (Po(op)) (D) indicate that depletion of Spef2 affects the trabecular bone content and structure. (E–G) Cortical bone volume (BV) (E), surface (BS) (F) and connectivity (conn) (G) suggests decreased bone volume and structure in the Spef2 KO vertebra. Error bars ± SD; * = p < 0,05; ** = p < 0,01; *** = p < 0,001.