Figure 2.

MVA-EBOV protection study in guinea pigs. (a) Survival curves for animals primed at week 0 and boosted at week 4 with MVA-EBOV or MVAwt. Controls are unvaccinated animals. At 8 weeks (day 0) all animals were challenged with the EBOV-Mayinga-based GPA-EBOV. (b) Body weight changes post challenge. (c) Anti-GP-specific Ab measured pre-immunization (pre), at 4 weeks after the prime (Wk4) and 2 weeks after the boost (Wk6). (d) Neutralizing Ab measured as 50% focus reduction neutralization titer (FRNT₅₀). Significance levels are indicated as follows: p < 0.05 (*), p < 0.01 (**), p < 0.001 (***) and p < 0.0001 (****).