Table 1.
Comparison of IOPs between different treatment groups.
| Comparison | Days | IOP differences between Means (mmHg) ± SEM | P-value (As indicated by 1-Way ANOVA followed by Dunnett posthoc test) | Significance signs in Fig. 2 |
|---|---|---|---|---|
| Vehicle (n = 10) v/s DEX-Ac (n = 18) | 0 | 0.08 ± 0.0.5 | P > 0.05 | N.S |
| 3 | 5.2 ± 0.9 | P < 0.001 | **** | |
| 7 | 6.9 ± 0.9 | P < 0.001 | **** | |
| 11 | 8.4 ± 0.7 | P < 0.001 | **** | |
| 14 | 9.7 ± 0.8 | P < 0.001 | **** | |
| 18 | 8.9 ± 0.9 | P < 0.001 | **** | |
| 25 | 10.25 ± 0.7 | P < 0.001 | **** | |
| 28 | 9.4 ± 0.9 | P < 0.001 | **** | |
| 32 | 10.54 ± 0.9 | P < 0.001 | **** | |
| 36 | 10.6 ± 1.2 | P < 0.001 | **** | |
| 40 | 10.74 ± 0.9 | P < 0.001 | **** | |
| 43 | 9.67 ± 0.7 | P < 0.001 | **** | |
| Vehicle (n = 10) v/s DEX-Ac + Ad5.hGRβ (n = 18) | 0 | 0.7 ± 0.4 | P > 0.05 | N.S |
| 3 | 4.3 ± 0.8 | P < 0.001 | **** | |
| 7 | 6.4 ± 0.9 | P < 0.001 | **** | |
| 11 | 8.6 ± 0.6 | P < 0.001 | **** | |
| 14 | 8.5 ± 1.08 | P < 0.001 | **** | |
| 18 | 9 ± 1.0 | P < 0.001 | **** | |
| Vehicle (n = 10) v/s DEX-Ac + Ad5.Null (n = 12) | 0 | 0.8 ± 0.5 | P > 0.05 | N.S |
| 3 | 5.1 ± 0.7 | P < 0.001 | **** | |
| 7 | 6.7 ± 1.0 | P < 0.001 | **** | |
| 11 | 8.8 ± 0.7 | P < 0.001 | **** | |
| 14 | 11.15 ± 0.7 | P < 0.001 | **** | |
| 18 | 7.5 ± 1.0 | P < 0.001 | **** | |
| After Adenoviral injections at Day 18 | ||||
| DEX-Ac (n = 18) v/s DEX-Ac + Ad5.hGRβ (n = 18) | 25 | 10.16 ± 0.6 | P < 0.001 | #### |
| 28 | 11.1 ± 0.87 | P < 0.001 | #### | |
| 32 | 11.16 ± 0.8 | P < 0.001 | #### | |
| 36 | 12.73 ± 1.1 | P < 0.001 | #### | |
| 40 | 10.85 ± 1.2 | P < 0.001 | #### | |
| 43 | 12.97 ± 1.0 | P < 0.001 | #### | |
| DEX-Ac (n = 18) v/s DEX-Ac + Ad5.Null (n = 12) | 25 | 2.4 ± 0.7 | P < 0.05 | |
| 28 | 1.6 ± 1.0 | P > 0.05 | N.S | |
| 32 | 2.2 ± 0.9 | P < 0.05 | N.S | |
| 36 | 2.5 ± 1.2 | P > 0.05 | N.S | |
| 40 | 3.0 ± 1.8 | P > 0.05 | N.S | |
| DEX-Ac + Ad5.Null (n = 12) v/s DEX-Ac + Ad5.hGRβ (n = 18) | 25 | 7.6 ± 0.8 | P < 0.001 | ++++ |
| 28 | 9.4 ± 1.0 | P < 0.001 | ++++ | |
| 32 | 8.9 ± 0.8 | P < 0.001 | ++++ | |
| 36 | 10.22 ± 1.1 | P < 0.001 | ++++ | |
| 40 | 7.7 ± 2.0 | P < 0.001 | ++++ | |