FIG 6.

Histopathology and weight of pancreas of older C and TC mice. (A to F) H&E-stained pancreas sections of 8-month-old C mouse (A) and TC mice (B to F). Panel C is a higher magnification of the boxed area in panel B. Extreme acinus cell atrophy is seen in panel D. (G) Oil Red O-stained pancreas section from 8-month-old TC mouse. (H) Pancreas weight/body weight of C and TC male and female mice. is, islet of Langerhans; ac, acinar cells; A, adipocytes; L, lipid. Arrowheads indicate immune infiltrates. The arrow indicates area of fibrosis. The area circumscribed by the dotted line in panel F is a ductal proliferative complex. Scale bars, 50 μm.