TABLE 1.
Differences in gene expression in pancreas of TC and C micea
| Gene designation and regulation status | Gene name | Fold change | Disease(s) or function |
|---|---|---|---|
| Upregulated | |||
| 1810009J06Rik | RIKEN cDNA 1810009J06 | 21.6 | |
| Gm2663 | Predicted gene 2663 | 20.1 | |
| Lgals9 | Lectin, galactose binding, soluble 9 | 12.2 | Metabolic |
| Igkv8-30 | Immunoglobulin kappa chain variable 8-30 | 7.5 | |
| Ighv3-6 | Immunoglobulin heavy variable 3-6 | 6.0 | |
| Oas2 | 2-5 Oligoadenylate synthetase 2 | 5.5 | Organismal injury |
| Igkv6-13 | Immunoglobulin kappa variable 6-13 | 5.0 | |
| Ifi27 | Interferon, alpha-inducible protein 27 | 4.9 | |
| Bst2 | Bone marrow stromal cell antigen 2 | 4.5 | |
| Stat1 | Signal transducer and activator of transcription 1 | 4.1 | |
| Tgtp2 | T cell specific GTPase2 | 3.7 | |
| Obp2b | Odorant binding protein 2B | 3.6 | |
| Ighv1-4 | Immunoglobulin heavy variable 1-4 | 3.6 | |
| Ccl8 | Chemokine (C-C motif) ligand 8 | 3.6 | Endocrine |
| Ifi44 | Interferon-induced protein 44 | 3.5 | Gastrointestinal |
| Ighv1-7 | Immunoglobulin heavy variable V1-7 | 3.4 | |
| H2-Q8 | Histocompatibility 2, Q region locus 8 | 3.4 | |
| Igkv6-15 | Immunoglobulin kappa variable 6-15 | 3.4 | |
| Ighv8-5 | Immunoglobulin heavy variable V8-5 | 3.4 | |
| Gbp10 | Guanylate-binding protein 10 | 3.4 | |
| Jchain | Immunoglobulin joining chain | 3.3 | Gastrointestinal, immunological, organismal injury |
| Ctss | Cathepsin S | 3.3 | Endocrine, gastrointestinal, immunological, metabolic, organismal injury, inflammatory response |
| Gm17757 | Predicted gene, 17757, noncoding RNA | 3.2 | |
| Ighv14-1 | Immunoglobulin heavy variable 14-1 | 3.1 | |
| Igkv1-133 | Immunoglobulin kappa variable 1-133 | 3.0 | |
| H2-K1 | Histocompatibility 2, K1, K region | 2.9 | |
| Apod | Apolipoprotein D | 2.7 | |
| H2-Eb1 | Histocompatibility 2, class II antigen E beta | 2.7 | |
| Lgals3bp | Lectin, galactose-binding, soluble, 3 binding protein | 2.7 | |
| Downregulated | |||
| Mir3966 | MicroRNA 3966 | −1.4 | |
| Olfr228 | Olfactory receptor 228 | −1.4 | |
| Cachd1 | Cache domain containing 1 | −1.6 | |
| Snora36b | Small nucleolar RNA, H/ACA box 36B | −1.7 | |
| Slc39a5 | Solute carrier family 39 (metal ion transporter), member 5 | −1.7 | Metabolic |
| Tmem30b | Transmembrane protein 30B | −1.7 | |
| Glp1r | Glucagon-like peptide 1 receptor | −1.7 | Organismal injury |
| Ptprn2 | Protein tyrosine phosphatase, receptor type, N polypeptide | −1.7 | |
| Prlr | Prolactin receptor | −1.7 | |
| Gm25482 | Predicted gene, 25482 | −1.8 | |
| Wars | Tryptophanyl-tRNA synthetase | −1.8 | |
| Gls2 | Glutaminase 2 (liver, mitochondrial) | −1.9 | Organismal injury |
| Sult1c2 | Sulfotransferase family, cytosolic, 1C, member 2 | −2.0 | |
| Hbb-bs | Hemoglobin, beta adult s chain | −2.2 | |
| Hbb-bt | Hemoglobin, beta adult t chain | −3.1 |
a
The top 30 genes that have the largest fold increase and all genes with the largest fold decrease in expression, as well as the lowest P value, are listed. Genes having function in the 7 diseases or functions most affected by HuR overexpression are in boldface.