FIG 5 .

Role of macrophages in C. dubliniensis-induced protection. Mice (n = 10/group) previously given the primary challenge of C. dubliniensis/S. aureus (14 days prior) were injected i.p. with liposome-encapsulated clodronate (which results in ~90% depletion of resident peritoneal macrophages), liposomes only, or PBS 1 day prior to rechallenge with C. albicans/S. aureus. Animals receiving no primary challenge also served as the positive (lethal) controls. Mice were monitored for 10 days post-rechallenge. *, significantly different from control (P < 0.02) by log rank Mantel-Cox test.