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. 2017 Jun 30;32(1):11–20. doi: 10.1038/leu.2017.171

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Vitamin C treatment leads to demethylation at enhancers that become active in the myeloid lineage specifically. A depiction of the hierarchical haematopoietic differentiation pathway from HSC into mature cells of the erythroid (top), myeloid (middle) and lymphoid (bottom) lineages; (a) a linear representation of mean H3K4me1 signal during lineage commitment; and (b) a boxplot representing log10(H3K4me1 signal) at enhancers in mature cell types of each lineage at previously identified enhancers overlapping deMRs (orange), iMRs (blue) or a random set (n=1000; grey). HSC, hematopoietic stem cells.