Table 1.

L. pneumophila Dot/Icm effectors involved in ubiquitination.

Effectors (gene number)	Aliases	Interactor/Substrate	Enzymatic activity	Function	References
lpg0171	legU1	SKP1, Cullin 1, BAT3	F-Box protein, E3 ubiquitin ligase	Unknown	Ensminger and Isberg, 2010
lpg1408	licA	SKP1	F-Box protein	Unknown	Ensminger and Isberg, 2010
lpg2144/lpp2082	legAU13/ankB	SKP1, Cullin 1, Parvin B	F-Box protein, E3 ubiquitin ligase	Recruitment of polyubiquitinated species to LCV; Generation of amino acids for L. pneumophila replication	Price et al., 2009, 2011; Ensminger and Isberg, 2010; Lomma et al., 2010
lpg2224	PpgA	Unknown	F-Box protein	Unknown	Ensminger and Isberg, 2010
lpg2525	–	Unknown	F-Box protein	Unknown	Ensminger and Isberg, 2010
lpp2486	–	Unknown	F-Box protein	Unknown
lpg2455	GobX	Unknown	U-Box protein, E3 ubiquitin ligase	Unknown	Lin et al., 2015
lpg2830	LegU2/LubX	Clk1, SidH	U-Box protein, E3 ubiquitin ligase	SidH degradation	Kubori et al., 2008, 2010
lpg2510 lpg2511	SdcA and SidC	Unknown	E3 ubiquitin ligase	Recruitment of ER vesicles and polyubiquitinated species to LCV	Hsu et al., 2014
lpg0234	SidE	Rab1, Rab6a, Rab30, Rab33b, Rtn4	All-in-one ubiquitin conjugation enzyme; Deubiquitinase	Intracellular replication; regulation of ubiquitin dynamics on the LCV; Recruitment of ER markers to the LCV; ER tubule Rearrangement.	Sheedlo et al., 2015; Bhogaraju et al., 2016; Qiu et al., 2016; Kotewicz et al., 2017
lpg2153	SdeC
lpg2156	SdeB
lpg2157	SdeA
lpg1148	LupA	Unknown	Deubiquitinase	Unknown	Urbanus et al., 2016
lpg2155	SidJ	Rab1, Rab6a, Rab30, Rab33b, Rtn4	Phosphodiesterase, Deubiquitinase	Recruitment of ER markers to the LCV; Regulation of SidEs-mediated substrates modification	Liu and Luo, 2007; Qiu et al., 2017