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(A) Hydrodynamic diameter of diphtheria toxoid (DT) (8.72 ± 2.83 nm, mean ± SD, n = 3). (B) Hydrodynamic diameter of tetanus toxoid (TT) (13.5 ± 5.6 nm, mean ± SD, n = 3). (C) Release of DT and TT in release buffer measured by intrinsic fluorescence (D) release of imiquimod (IMQ) from nanoporous microneedle arrays in phosphate-buffered saline measured by high-performance liquid chromatography.
