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. 2017 Dec 22;8:1867. doi: 10.3389/fimmu.2017.01867

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At least a portion of this work is authored by Jeffrey I. Cohen on behalf of the U.S. Government and, as regards Dr. Cohen and the US government, is not subject to copyright protection in the United States. Foreign and other copyrights may apply.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathologic features of a 47-year-old female patient with T cell chronic active Epstein–Barr virus (EBV) disease. (A) Hematoxylin and eosin stain. Small- to medium-sized lymphocytes without significant atypia infiltrate the bone marrow clot. (B) EBV-encoded RNA in situ hybridization. The brown staining lymphocytes are positive for EBV RNA.