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. 2017 Aug 16;43(3):492–502. doi: 10.1038/npp.2017.149

Figure 3.

Figure 3

Impaired nest building for Fmr1-KO mice outside home cage. (a) Illustration of nest building performance for individual WT and Fmr1-KO mice in their home cage (left), familiar open field (OF, familiarization 1 h/day during 9 days), and new cage (right). The pictures were taken at the time indicated (between 1 h and 5 h after introduction of the nest building material). Note that the WT mouse had terminated nest building after 90 min in all tested conditions, whereas the KO mouse performed well in its home cage but not in the familiar open field or in a new cage. (b) Summary plots of nest building scores in home cage, new cage, and familiar open field for WT and Fmr1-KO mice. (c) Summary plot of nest building over time for WT and Fmr1-KO mice in a new cage. Note that WT mice complete nest building within 2 to 3 h in any tested condition, whereas KO mice have delayed nest building. (b, c) *Statistically significant effect of genotype (p<0.05).