Table 3.
Associations of miRNA Δage with prevalent CHD, diabetes, hypertension, and cardiometabolic traits
| Trait/Disease | Chronological age | miRNA Δage | ||||||
|---|---|---|---|---|---|---|---|---|
| Estimated Beta | SE | T‐Value | P‐Value | Estimated Beta | SE | T‐Value | P‐Valuea | |
| CHD | 15.28 | 0.84 | 18.20 | 8.72E‐72 | 5.42 | 0.64 | 8.45 | 3.76E‐17 |
| Hypertension | 9.45 | 0.64 | 14.84 | 2.76E‐48 | 1.62 | 0.53 | 3.05 | 2.34E‐03 |
| Diabetes | 8.42 | 1.05 | 8.02 | 1.28E‐15 | 1.01 | 0.77 | 1.30 | 1.94E‐01 |
| Total cholesterol | 0.82 | 0.05 | 15.84 | 3.81E‐54 | −0.05 | 0.07 | −0.82 | 4.14E‐01 |
| High‐density lipoprotein | 0.07 | 0.02 | 2.73 | 6.34E‐03 | 0.06 | 0.03 | 2.00 | 4.61E‐02 |
| Triglycerides | 0.26 | 0.10 | 2.51 | 1.21E‐02 | −0.18 | 0.13 | −1.36 | 1.73E‐01 |
| Systolic blood pressure | 0.55 | 0.02 | 26.27 | 5.09E‐136 | 0.10 | 0.03 | 3.78 | 1.58E‐04 |
| Diastolic blood pressure | 0.08 | 0.01 | 6.00 | 2.24E‐09 | 0.06 | 0.02 | 3.65 | 2.67E‐04 |
| Glucose | 0.31 | 0.02 | 15.81 | 5.78E‐54 | 0.07 | 0.02 | 2.86 | 4.30E‐03 |
| Body mass index | 0.004 | 0.01 | 0.52 | 6.01E‐01 | −0.002 | 0.01 | −0.24 | 8.11E‐01 |
a
The P‐value threshold for significance for miRNA Δage vs. traits analyses (P < 0.005) was determined by the Bonferroni method (0.05/10). Significant P‐values are shown in boldface.