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. 2018 Jan 12;10:453. doi: 10.3389/fnmol.2017.00453

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Copyright © 2018 Chen, Xu, Tu, Xu, Zhou, Cheng, Yang, Yang, Zheng, He, Deng, Ge, Li, Song, Zhao and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological staining and OCT analyze of retina. (A) Cavities are observed (blue circle) in the retina of RS1-KI mice at 4 weeks compared with WT mice. (B) Statistical analysis shows the thickness of OS and IS became significantly shorted in RS1-KI mice, compared with WT. (C) Retina section exhibits structural changes that include mislocalization (cyan arrows) and dissection through the inner nuclear layer (blue arrows), poorly formed and irregular outer plexiform layer (yellow arrow in RS1-KI).OS, outer segment of photoreceptor; IS, inner segment of photoreceptor; ONL, outer nuclei layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; RGC, retinal ganglion cell. (D) The outer nuclear layer of RS1-KI mice is much thinner than that of WT. ^∗∗∗P < 0.001.