Fig. 2.

Clinical disease in SINV-infected WT B6, Ifngr1^−/− and Ifng^−/− mice. (a) SINV-infected WT B6, Ifngr1^−/− and Ifng^−/− mice were evaluated daily for the presence of clinical disease, with data presented as the proportion of mice showing clinical signs each day for 23–38 mice per strain combined from three to five independent experiments. (b) Body weight was measured daily and normalized to the body weight at 0 DPI, with data represented as the mean±sem for 23–38 mice per strain combined from three to five independent experiments; dotted line indicates initial body weight. (c) Body temperature was measured rectally daily, with data represented as the mean±sem for eight mice per strain; dotted line indicates reported normal rectal temperature for mice. (d) Daily feed consumption was measured for two or three mice housed per cage, with feed intake of SINV-infected mice normalized first to that of mock-infected mice for each strain for each day and then to the feed intake at 0 DPI for that cage; data are presented as the mean amount of consumed feed±sem for 7–10 cages combined from two independent experiments; dotted line indicates baseline feed intake.