Fig. 4.

Effect of IFN-γ on SINV-specific antibody production. Anti-SINV IgM (a, c, e) and IgG (b, d, f) were measured in the serum (a, b), brains (c, d) and spinal cords (e, f) of WT B6, Ifngr1^−/− and Ifng^−/− mice by ELISA. Data are presented as mean ODs±sem for three to four mice per strain per time point; *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001, WT B6 vs Ifngr1^−/−; ^#P<0.05, ^###P<0.001, ^####P<0.0001, WT B6 vs Ifng^−/−; ^†P<0.05, ^††P<0.01, Ifngr1^−/− vs Ifng^−/−, Tukey’s multiple comparisons test.