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. 2017 Dec 1;37(2):201–218. doi: 10.15252/embj.201797630

Figure 2. Validation and tumorigenic potential of early passage aneuploid cells.

Figure 2

  1. Shallow whole‐genome sequencing (copy number profiles) of large T antigen immortalized, early passage MEFs after exposure to Cre recombinase and sorted for control (hCD2 Plus) and ICL (hCD2 Minus) cells for chromosomes 12, 14 and 9 and 10.
  2. Tumor growth curve after early passage ICL cells were injected into flanks of athymic nude mice (n = 5 per group and error bars denote SEM, *P < 0.05 for Ch9 and Ch14). Two‐tailed unpaired t‐test was used to determine statistical significance.