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. 2017 Dec 1;37(2):201–218. doi: 10.15252/embj.201797630

Figure 7. Effects of ploidy on the tumorigenic potential of ICL cells.

Figure 7

  1. Flow cytometry analysis of tail blood from Ch10/+ (control) at 30 days post‐tamoxifen administration, Ch10/+; Id1 Cre/+ at 30 days post‐tamoxifen administration, and Ch10/+; Id1Cre/+ at 80 days post‐tamoxifen administration.
  2. Analysis from the Mitelman database for the fraction of human solid tumors that have lost (top) or gained (bottom) individual chromosomes that have modal chromosome number > 2N or ˜2N (n = 3,459 cases for modal number > 2N and n = 12,464 cases for modal number ˜2N, top: ***P < 0.0001 for chromosomes 1–22, X and *P < 0.05 for chromosome Y; bottom: ***P < 0.0001 for all chromosomes). Two‐tailed two‐sample t‐test to compare sample means was used to determine statistical significance.
  3. Analysis from the Mitelman database for the fraction of human solid tumors that have lost or gained any chromosome that have modal chromosome number > 2N or ˜2N (n = 3,459 cases for modal number > 2N and n = 12,464 cases for modal number ˜2N, ***P < 0.0001 for both modal number > 2N and ˜2N). Two‐tailed two‐sample t‐test to compare sample means was used to determine statistical significance.