Table 2. Levels of Total Methyl, B₁p(POB)B₂, B₁p(PHB)B₂ Phosphate Adducts, and Total Methyl, POB, PHB Base Adducts in Lung Tissue of Rats Treated with 5 ppm of NNK, (S)-NNAL, and (R)-NNAL in Drinking Water for 10, 30, 50, or 70 Weeks^a.

	DNA adduct (fmol/mg DNA)
	phosphate adducts			base adductsb
time (weeks)	B1pMeB2	B1p(POB)B2c	B1p(PHB)B2d	methyl	POB	PHB	total
NNK
10	2290 ± 546	475 ± 95	6390 ± 457	213 ± 27	4600 ± 440	1200 ± 49	15200 ± 844
30	4480 ± 119	417 ± 43	8160 ± 654	100 ± 65	5570 ± 195	1530 ± 104	20300 ± 705
50	3820 ± 215	346 ± 41	4000 ± 291	79 ± 15	5110 ± 327	1390 ± 74	14700 ± 495
70	4510 ± 129	218 ± 15	3950 ± 223	34 ± 48	2300 ± 473	869 ± 143	11900 ± 560
(S)-NNAL
10	1120 ± 217	4650 ± 356	3670 ± 67	269 ± 178	3180 ± 664	847 ± 34	13700 ± 807
30	1020 ± 290	2910 ± 109	4180 ± 119	114 ± 25	3950 ± 371	1210 ± 30	13400 ± 499
50	872 ± 309	1310 ± 77	3480 ± 79	78 ± 29	4530 ± 335	1250 ± 48	11500 ± 472
70	995 ± 258	1180 ± 204	3820 ± 582	49 ± 22	4470 ± 265	1270 ± 311	11800 ± 784
(R)-NNAL
10	874 ± 146	136 ± 32	4530 ± 368	5 ± 2	323 ± 36	4880 ± 721	10700 ± 824
30	1430 ± 140	135 ± 30	6670 ± 211	17 ± 23	490 ± 81	7440 ± 507	16200 ± 574
50	1100 ± 257	175 ± 17	6280 ± 336	7 ± 6	720 ± 46	6670 ± 885	15000 ± 982
70	763 ± 90	46e	6920 ± 436	4 ± 5	545 ± 112	6170 ± 1770	14400 ± 1830

^aValues are presented as means ± SD (n = 3 or 5).

^bThe data for base adduct levels are from Balbo, S. et al. (2014) Carcinogenesis, 35, 2798–2806.

^cThe data for B₁p(POB)B₂ phosphate adduct levels in NNK-treated rats are from Ma, B. et al. (2015) Chem. Res. Toxicol., 28, 2151–2159.

^dThe data for B₁p(PHB)B₂ phosphate adduct levels in NNK-treated rats are from Ma, B. et al. (2017) Carcinogenesis, in press. The data for B₁p(POB)B₂ and B₁p(PHB)B₂ phosphate adduct levels in (R)-NNAL- or (S)-NNAL-treated rats are from Ma, B. et al. (2017) Mutagenesis, in press.

^eSingle measurement.