Table 2.

Association between paternal SSRI use before conception and ASD in offspring

Paternal SSRI use before conception	Offspring with ASD, n	Follow-up number of person-years	HR (95% CI)
			Crude	Model 1*	Model 2†
No use during the last 3 months prior to conception	7473	6 765 205	Ref	Ref	Ref
Use during the last 3 months prior to conception	104	61 555	1.62 (1.33 to 1.96)	1.54 (1.27 to 1.88)	1.43 (1.18 to 1.74)
Subanalysis: paternal SSRI use during the last 1  year before conception
No use during the last 1 year prior to conception	7429	6 736 654	Ref	Ref	Ref
Use only from the last 1 year to the last 3 months prior to conception	71	39 422	1.71 (1.35 to 2.16)	1.66 (1.31 to 2.09)	1.54 (1.21 to 1.94)
Use only during the last 3 months prior to conception	20	14 738	1.29 (0.83 to 2.00)	1.24 (0.80 to 1.93)	1.17 (0.75 to 1.82)
Use both before and during the last 3 months prior to conception	57	35 946	1.52 (1.17 to 1.97)	1.43 (1.10 to 1.86)	1.32 (1.02 to 1.72)

*Adjusted for calendar year of birth, sex, parity, mother age, father age, maternal smoking, mother psychiatric history, maternal AD use during pregnancy.

†Model 1 further adjusted for father psychiatric history.

AD, antidepressant drug; ASD, autism spectrum disorder; n, number; SSRI, selective serotonin reuptake inhibitor.