Table 4.

Paternal SSRI use before pregnancy and ASD in exposed and unexposed siblings from 5479 families

Paternal SSRI use before conception	Offspring, n	Offspring with ASD, n	HR (95% CI)
			Crude	Model 1*
No use during the last 3 months prior to conception	2792	45	Ref	Ref
Use during the last 3 months prior to conception	2687	23	0.53 (0.31 to 0.91)	0.74 (0.34 to 1.59)

*Adjusted for sex, parity, mother age, father age, maternal smoking, maternal AD use during pregnancy.

AD, antidepressant drug; ASD, autism spectrum disorder; n, number; SSRI, selective serotonin reuptake inhibitor.