Table 1.

Inclusion and exclusion criteria

Inclusion criteria

Exclusion criteria

Age ≥55 years Tobacco pack-years ≥30 If former smoker, quit within 15 years Presence of COPD* Affiliation to the French social security system

Chest CT examination in the 12 months prior to eligibility assessment, except chest CT made in the prior 6 weeks Known pulmonary nodule or abnormality warranting radiological follow-up or further diagnostic work-up Treatment for, or evidence of, any cancer other than skin basocellular carcinoma in the 5 previous years Acute respiratory tract infection treated with antibiotics in the previous 12 weeks Unexplained weight loss ≥10% in the previous 12 months Recent haemoptysis History of lung volume reduction with coils, glue or valves Thoracic metallic implants or devices such as Harrington fixation rods Participation in another cancer screening trial Participation in a cancer prevention study, other than a smoking cessation study Vulnerable persons: adults under guardianship, adults under trusteeship or persons deprived of their liberty, participants under 18 years old, medical and/or psychiatric problems

*Compatible medical history and fixed airflow limitation as defined by postbronchodilator FEV1/FVC <0.7.³⁹

COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.