Table 2.
Endoscopic procedures and histologic characteristics
| MBM | ER-cap | p-value | |
|---|---|---|---|
|
| |||
| Endoscopic complete removal of lesions | 42/42 (100%) | 42/42 (100%) | 1 |
| Median number of resections | 5 (IQR: 4–6) | 4 (3–5) | 0.69 |
| Median MBM resection time* | 11 minutes (IQR: 7–16) | 22 (IQR: 12–31) | <0.0001 |
| Complications | |||
| clinically not relevant bleeding during ER | 1 | 5 | |
| acute (during ER) | 1 moderate (perforation, treated conservatively) | 0.93 | |
| early (0–48 hrs) | |||
| delayed (>48 hrs) | 9 (mild stenoses, clinically not relevant) | 8 (mild stenoses, clinically not relevant) | |
| Costs of disposables (€) | 200 (IQR: 200–400) | 251 (IQR: 210–300) | 0.04 |
|
| |||
| Median max. dimensions of individual resection specimens | 18 x 12 mm (IQR: 15–21/10–16) | 20 x 15 (IQR: 15–21/11–20) | 0.07 |
| Median max. thickness of resected lesions** | 2050 μm (IQR: 1460–2332) | 1725 (IQR: 1375–2188) | 0.06 |
| Median max. submucosal thickness** | 900 μm (IQR: 521–1207) | 800 (IQR: 488–1063) | 0.27 |
| Worst histology of ER specimens: | 0.62 | ||
| LGIN | 1 (2%) | 2 (5%) | |
| MGIN | 2 (5%) | 2 (5%) | |
| HGIN | 16 (38%) | 17 (40%) | |
| ESCC | 23 (55%) | 21 (50%) | |
| Max. penetration depth of ESCC: | 0.89 | ||
| m2 | 12 | 9 | |
| m3 | 7 | 8 | |
| sm | 5 | 4 | |
| Max. differentiation grade of ESCC: | 0.56 | ||
| G1 | 3 | 6 | |
| G2 | 10 | 13 | |
| G3 | 11 | 2 | |
*
Time between introduction of endoscope with assembled MBM or ER-cap kit and end of the ER procedure, inclusive of removal of resection specimens and treatment of complications
**
Maximum thickness of the reconstructed lesion
NS: not significant; IQR: interquartile range; LGIN: low grade intraepithelial neoplasia; MGIN: moderate grade intraepithelial neoplasia; HGIN: high grade intraepithelial neoplasia; ESCC: esophageal squamous cell carcinoma