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General involvement of human CYP isoenzymes in initial metabolic steps of 3-MeO-PCP and 3-MeO-PCPy.
|
CYP
1A2 |
CYP
2A6 |
CYP
2B6 |
CYP
2C8 |
CYP
2C9 |
CYP
2C19 |
CYP
2D6 |
CYP
2E1 |
CYP
3A4 |
CYP
3A5 |
|
|---|---|---|---|---|---|---|---|---|---|---|
| 3-MeO-PCP | ||||||||||
| O-Demethylation | + | ++ | + | |||||||
| Piperidine-hydroxylation | ++ | + | ||||||||
| Cyclohexyl-hydroxylation | ++ | |||||||||
| 3-MeO-PCPy | ||||||||||
| O-Demethylation | + | + | ++ | |||||||
| Pyrrolidine-hydroxylation | ++ |
