Table 3.

Unadjusted and adjusted population risk for having cognitive decline to below the baseline cut-off for the corresponding cognitive domain during the study visits [1–4]

	Univariate			Multivariate*
	RR	95% CI		p value	RR	95% CI		p value
Cys
Memory domain	0.54	0.20	1.46	0.22	0.61	0.20	1.87	0.39
Executive function domain	1.11	0.66	1.86	0.70	1.08	0.65	1.78	0.78
Working memory domain	0.68	0.42	1.08	0.10	0.56	0.35	0.90	0.05
CYSS
Memory domain	0.89	0.50	1.58	0.69	0.92	0.51	1.66	0.78
Executive function domain	0.96	0.60	1.52	0.86	0.82	0.51	1.31	0.41
Working memory domain	1.15	0.72	1.85	0.56	1.07	0.65	1.76	0.78
GSH
Memory domain	0.83	0.43	1.58	0.57	0.64	0.31	1.32	0.23
Executive function domain	1.82	1.10	3.01	0.02	1.70	1.02	2.85	0.04
Working memory domain	0.97	0.60	1.57	0.91	1.08	0.63	1.86	0.78
GSSG
Memory domain	1.15	0.72	1.85	0.56	1.07	0.65	1.76	0.78
Executive function domain	1.18	0.65	2.15	0.59	1.56	0.81	3.04	0.19
Working memory domain	0.83	0.43	1.58	0.57	0.64	0.31	1.32	0.23
CRP
Memory domain	1.43	0.61	3.34	0.41	0.94	0.59	1.50	0.94
Executive function domain	1.13	0.63	2.05	0.68	0.84	0.45	1.54	0.84
Working memory domain	1.05	0.67	1.64	0.83	0.94	0.59	1.50	0.94

*Models adjusted for race, age, gender, systolic blood pressure, body mass index, education, statin, and antihypertension medication use and baseline performance

CRP C-reactive protein, CYS cysteine, CYSS cystine, GSH glutathione, GSSG glutathione disulfide