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. 2018 Jan 1;8(3):710–722. doi: 10.7150/thno.19154

Figure 4.

Figure 4

Gadolinium-enhanced magnetic resonance imaging after wakefulness or ketamine/xylazine general anesthesia. (A) Schematic representation of the experimental design of the Magnetic Resonance Imaging (MRI) experiments. (B) Representative high-resolution T1-weighted images 60 min after intracisternal injection of DOTA-Gd (1 µL) in awake (top) and anesthetized mice (bottom). (C) Corresponding quantification of the signal intensity in four different regions of interest (Cerebellum, Olfactory Bulbs (OB), Motor Cortex and Hippocampus). (n=5 mice per group). Scale bar: 2 mm.