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. 2018 Jan 1;8(3):767–784. doi: 10.7150/thno.21209

Figure 9.

Figure 9

(A) Changes in body weights of treated mice compared to control groups. (B) and (C) The blood levels of BUN and creatinine, illustrating kidney function; CK, illustrating cardiac function; and ALT and ALP, illustrating liver function, in control mice and mice injected i.v. with the activatable (OFF/ON) SiNc-PNP, assessed after 24 h, 96 h and 1 week. (D, E) Images of nude mice, illustrating the lack of phototoxicity (skin damage). (F) An in vitro micronucleus assay (formation of micronuclei) was used to determine the genotoxicity of the activatable SiNc-PNP. CHO-K1 cells were treated with the activatable SiNc-PNP (90 µg/mL) for the experiment group, fresh media for negative control, or methyl methanesulfonate (MMS, 50 µg/mL) for a positive control. Inset: fluorescence images of CHO-K1 cells nuclei treated for 24 h with MMS (left) and activatable SiNc-PNP (right). *P < 0.05 when compared with positive control (media).