Fig. 5.

Protein clustering reveals major biological and molecular signatures of ADLP^APT mice. a Hierarchical clustering of differentially expressed proteins (DEP^APTs) between ADLP^APT and wild-type mice (732 proteins; ANOVA FDR < 0.05). The DEPs^APT were clustered into five types of expression pattern. The protein expression level is the normalized protein abundance represented after Z-normalization. Scatter plot of enriched Gene Ontology (GO) terms in protein cluster 2 (down-regulated proteins) and cluster 5 (up-regulated proteins) are shown in the right panel. The -log10 (P-value) is plotted against the fold-enrichment of each GO term. b Heatmaps showing the expression levels of the proteins involved in the GO terms, such as synapse proteins and cytoskeleton binding proteins, in cluster 2 (down-regulated proteins). c Heatmaps for the expression levels of co-regulated proteins corresponding to the GO terms, such as lysosome, endosome, leukocyte-mediated immunity, and phagocytosis, in cluster 5 (up-regulated proteins)