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. 2018 Jan 16;15:18. doi: 10.1186/s12974-017-1049-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Expression of EBV latent and lytic genes in laser-cut MS brain immune infiltrates. Expression levels of four EBV latent genes (EBER1, EBNA3A, LMP1, LMP2A) and two EBV lytic genes (BZLF1, gp350/220) in immune infiltrates (n = 75) isolated from the meninges and WM of 11 MS cases were evaluated using preAmplification ddPCR. EBV genes were detected in samples from 9 MS cases; samples from 2 cases (MS154 and MS402) were negative. The percentages of samples positive for EBV genes were 22.7% (17/75) for EBER1, 10.7% (8/75) for EBNA3A, 17.3% (13/75) for LMP1, 4.0% (3/75) for LMP2A, 4.0% (3/75) for BZLF1, and 2.7% (2/75) for gp350/220. Gene expression values are presented as log of the ratio between target gene and reference gene (GAPDH) copy number