Table 1. ECHO trial operational metrics.

ECHO Performance Standard	Target (*=overall, at each site, in each arm)
#1 Accrual	Achieve target sample within ~18 months
#2 Method refusal	<5% of subjects*
#3 Retention	Per-visit completion of ≥90% and ≤10% of expected person-years lost*
#4 Method discontinuation	≤10% of all person-time off assigned method*
#5 HIV incidence	sufficient to meet the study objectives (≥3.5%/year)
#6 Ineligible enrolments	<1–2% of total*
#7 HIV endpoint enrolments	up-to-date for each DSMB review*
#8 Data quality	current for each DSMB, QC≤5/100 CRFs, fax time ≤7d*