Table 1. ECHO trial operational metrics.

ECHO Performance Standard	Target
#1 Accrual	Achieve target sample within ~18 months
#2 Method refusal	<5% of subjects *
#3 Retention	Per-visit completion of ≥90% and ≤10% of expected person-years lost *
#4 Method discontinuation	≤10% of all person-time off assigned method *
#5 HIV incidence	sufficient to meet the study objectives (≥3.5%/year)
#6 Ineligible enrolments	<1–2% of total *
#7 HIV endpoint reporting	up-to-date for each DSMB review *
#8 Data quality	current for each DSMB meeting, QC≤5/100 CRFs, ** fax time ≤7d **

* = overall, at each site, in each arm

** QC = quality control, CRFs = case report forms