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. 2018 Jan 16;11:6. doi: 10.1186/s13039-017-0353-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Immunohistochemical characterization of skin lesion. a Haematoxylin/eosin staining, ×4. b Haematoxylin/eosin staining, ×10, the dotted black line defines the border area between CLL and MM tumors. c, d and e Immunohistochemical positivity for CD20, CD5 and CD23 antigens. f Immunohistochemical negativity for CD3. g Presence of mutant BRAF only in MM lesion. h MIB1 expression to evaluate the neoplastic proliferation