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. 2018 Jan 16;10:7. doi: 10.1186/s13148-017-0437-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Mean values and standard deviation (relative expression) of SIRT-1 (a), HDAC2 (b), and DNA methylation levels (c) in tumor (T) and non-tumor (NT) lungs of LC and LC-COPD patients. Definition of abbreviations: miR, microRNA; SIRT-1, sirtuin-1; and HDAC2, histone deacetylase 2. Statistical significance: ^#p < 0.05, ^###p < 0.001 between non-tumor specimens of LC-COPD and non-tumor lungs of LC patients; ^§§§p < 0.001 between tumor lungs of LC-COPD and tumor specimens of LC patients; and n.s., non-significant differences between the study groups